Evaluation of acute toxicity for Abutilon indicum
By Shirish S. Pingale and Popat S. Virkar
The present study investigated the acute toxicity of Abutilon indicum plant material in Swiss
mice. The plant material was administered orally at dose ranging from 2gm to 10gm/Kg body
weight as well as 10g/Kg body weight plant material as well as 10ml/Kg juice of fresh leaves and
the animals were observed continuously for the first 4 hours for any behavior changes and they
were then kept under observation up to 14 days after drug administration to find out the
mortality. From the results it is concluded that Abutilon indicum plant material at doses of 10
g/kg as well as 10 ml/Kg is nontoxic since no marked changes in behavioral, food and water
intake were observed. The Abutilon indicum plant material was found to be safe. No lethality or
adverse toxic signs were seen during the experimental period and during 14 days observation
period. No delayed toxic signs were noted in all experimental groups. These findings suggest that
the Abutilon indicum could be relatively safe when administered orally in Swiss mice.
Keywords: Abutilon indicum, acute toxicity, mortality, Swiss mice.
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