Evaluation of analgesic activity of ethanolic extract of Sphaeranthus indicus
By B. R. Meher, J. Jena and B. G. Rath
The Sphaeranthus indicus has been widely used for its reported biological activity in indigenous
system of medicine. The present investigation was carried out to found the analgesic effect of
ethanolic extract of Sphaeranthus indicus in experimental animal models of pain. The analgesic
activity was evaluated by acetic acid induced writhing method in albino mice and by tail flick
latency method in albino rats respectively. The percentage protection against writhing showed
by ethanolic extract of SI in doses of 100, 200 and 400 mg/kg was 14.22, 36.90 and 62.20
respectively. In the tail flick model, the ethanolic extract of SI in the above doses increased the
pain threshold significantly after 30 min, 1, 2 and 4 h of administration. The ethanolic extract
Sphaeranthus indicus in different doses (100,200, and 400mg/kg, p.o) exhibited dose dependent
and significant analgesic activity in both models of pain.
Keywords: Analgesic, Sphaeranthus indicus, Acetic induced writhing, TFL.
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