Formulation and evaluation of oral floating tablets of Atenolol using Okra gum
By Edukondalu.V, Ashok Kumar.I, Jagadeesh.K, Pushpalatha.V, Satyanadam.SadeandLakshmi
The main aim of this study was to optimize and evaluate the floating tablets of atenolol that
prolongs the gastric residence time. Semi-synthetic polymer, HPMC K100M and natural
polymer i.e..okra gum were used as release retarding agents by its swelling nature . Sodium
bicarbonate was used as a gas-generating agent, Atenolol were prepared by direct compression
method. The prepared tablets were evaluated for physicochemical parameters and found to be
within range viz. hardness, swelling index, floating capacity, thickness, and weight variation.
Further, tablets were evaluated for in vitro release characteristics for 8 hrs. The concentration
of okra gum with a gas-generating agent was optimized to get the sustained release of atenolol
for 8hrs, drug release from all the formulations followed first order kinetics and higuchi’s
mechanism. The optimized (F6) formulation has better release rate. Based on the diffusion
exponent (n) value, the drug release was found to be diffusion controlled.
Keywords: Atenolol, HPMC, Okra gum, floating tablets.
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