Electro chemical study and polarographic assay of Clonazepam formulations
By Putta Chenna Rohini Kumar, Kodigutta Balaji, Minchala Pushpalatha, Chadive Sridevi
and Cirandur Suresh Reddy
Electrochemical reduction behaviour of clonazepam has been carried out, by employing d.c.
polarography, cyclic voltammetry, a.c. polarography and differential pulse polarography in the
supporting electrolytes of the pH ranging from 2.0 to 12.0. The two - step reduction waves are
found to be irreversible and diffusion controlled. Differential pulse polarography has been
developed for the quantitative estimation of clonazepam in different pharmaceutical
preparations without any prior separation using standard addition method. Kinetic parameters
such as transfer coefficient, diffusion coefficient and heterogeneous forward rate constant are
evaluated and reported. On the basis of the experimental results, a reduction mechanism is
suggested for clonazepam.
Keywords: Clonazepam, Electrochemical study, Mechanism, Pharmaceutical formulations.
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