Design and development of once-daily bi-layer matrix tablet of Baclofen using
HPMC K15:For the effective treatment of muscle spasm
By Upendra Kulkarni, Vedpathak Prasad A., Basawaraj S. Patil, Hariprasanna R.C and Rabbani G
In the present study, Baclofen bi-layer tablets were formulated consisting of two layers such as
fast releasing layer and sustaining layer. Fast releasing layer was prepared by using super
disintigrant like sodium starch glycolate and sustained release layer was prepared by using
synthetic polymer like hydroxy propyl methylcellulose K 15 (HPMC K15) by wet granulation
method. The tablets were evaluated for physico-chemical properties such as hardness, friability,
thickness, weight variation, drug content uniformity. The In vitro release studies were performed
in 0.1 N HCl for first two hr and in 7.4-pH phosphate buffer up to 24 h. It was observed that bilayer
matrix tablets having formulation code BH II which contained 65 % HPMC K15 were
successfully sustained the release of drug up to 24 h. FT-IR studies revealed that there was no
interaction between the drug and polymer used in the study.
Keywords: Bi-layer tablets, Baclofen, Sustained release, HPMC K15.
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