Development and in vitro evaluation of gastroretentive drug delivery
system of Losartan Potassium
By Lingaraj S. Danki, Reema U. Maind, S. Appala Raju and M. Prashanth Reddy
In the present study, development of Gastroretentive Drug Delivery System (GRDDS) of Losartan
potassium, an anti-hypertensive drug was designed to increase the gastric residence time.
Formulations were prepared using wet granulation method, employing polymers like HPMC
K4M, HPMC K15M, carbopol 934P and sodium alginate. Sodium bicarbonate and citric acid
were used as gas generating agents. Tablets were evaluated for various parameters like
hardness, friability, uniformity of weight, drug content uniformity, drug polymer interaction
studies, swelling index, in vitro floating studies, In vitro drug release and short term stability
studies. Drug release analysis on the basis of Higuchi-Korsmeyer model indicated that diffusion
is the predominant mechanism controlling the drug release. The drug polymer interaction studies
indicated no interaction. The short term stability study showed no significant change.
Keywords: Losartan potassium, Gastroretentive Drug Delivery System, HPMC, Carbopol 934P,
Click here to download the complete article in PDF Format