Formulation of Oro-dispersible tablets containing drug-resin complex
By Swapnil Umakant Wani, Prashant Shamkuwar, Ashwini Nagnath Yerawar
The purpose of this research was to formulate tasteless complexes of Fexofenadin Hydrochloride with Doshion P547 and to formulate tasteless complex into Oro-Dispersible tablets (ODT). Drug resin complexes (DRC) were characterized by suitable method. Fexofenadin Hydrochloride release from ODT is obtained at salivary and gastric pH. Infrared spectroscopy revealed complexation of –NH (drug) with Doshion P547. Drug release from ODT in salivary pH was insufficient to impart bitter taste. Complete drug release was observed at gastric pH in 2 hours. Doshion P547 is inexpensive, and the simple technique is effective for bitterness masking of Fexofenadin Hydrochloride.
Keywords: Fexofenadin Hydrochloride, Doshion P547, tasteless complex, Characterization, Oro-dispersible tablet
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