Formulation and in- vitro permeation studies of Ketoprofen-Ficus reticulata fruit mucilage transdermal patches
By Swetha T, Hindustan Abdul Ahad, Kishore Kumar Reddy, Chandra Sekhar A, Sivaji S, Anil Kumar B
The main objective of the present study was to develop matrix-moderated transdermal systems of Ketoprofen using various proportions of Ficus reticulata fruit mucilage. Physical evaluation was performed such as moisture content, moisture uptake, tensile strength, flatness and folding endurance. In-vitro penetration studies were performed in a Keshary-Chien diffusion cell. The matrix-type transdermal systems were prepared using Ketoprofen with Ficus reticulata fruit mucilage by the solvent evaporation technique. The interactions between Ketoprofen and Ficus reticulata fruit mucilage were performed. The transdermal patches were subjected to various physicochemical parameters viz., mechanical properties, permeation studies and skin irritation studies. The prepared patches possessed satisfactory pre-formulary and formulary characteristics. In-vitro permeation studies were performed using a Keshary-Chien diffusion cell across hairless Albino rat skin. Span 80, Glycerin and Propylene glycol in the formulation played a role as permeability enhancers. The patches were seemingly free of potentially hazardous skin irritation. The experimental results shows that the release of drug from the patch delayed in controlled manner as the proportion of Ficus reticulata increased. It was concluded that Ketoprofen can be developed as transdermal patches with Ficus reticulata fruit mucilage
Key words: Ketoprofen, Ficus reticulata fruit mucilage, transdermal patches, in-vitro permeation, skin irritation.
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