Formulation and evaluation of acyclovir microcapsules using biodegradable and non-biodegradable polymers 

By Krishnan P.N, Saraswathi R, Dilip C, Rama Rao N, Sambasiva Rao K.R.S, Raghvendra 

ABSTRACT

To formulate and evaluate Acyclovir microcapsules using biodegradable and non-biodegradable polymers namely egg albumin, guar gum and ethyl cellulose and its invitro evaluation. The Acyclovir microcapsules were prepared using different concentrations of egg albumin, guar gum and ethyl cellulose. The microcapsules were prepared using solvent diffusion method and heat coagulation method. The microcapsules were then studied for entrapment efficiency at two different stirring speeds, drug polymer compatibility and surface morphology. The invitro release study was also done. Further kinetic modeling was employed to find out the release mechanisms. Acyclovir loaded microcapsules formulated with guar gum showed an entrapment efficiency of 92.97%, with ethyl cellulose 91.96% and the entrapment efficiency with egg albumin was 90.61%. The SEM showed that the microcapsules were free flowing, non aggregated and spherical between 700-1000 µm in diameter. The surface was wavy in microcapsule formulated with guar gum, porous in microcapsules using ethyl cellulose and smooth in the case of microcapsules formulated with egg albumin. The FTIR spectrum showed that there is no interaction between the polymer and the drug. The invitro release study was found to be the best in the case of acyclovir microcapsules formulated with guar gum. The rate of drug release follows a time dependent process based on fickian diffusion and korsemeyer- peppas model that the drug release is by diffusion and by erosion. The acyclovir microcapsules using various polymers can be used as oral controlled delivery of the antiviral drug acyclovir. 

Key words. Polymers, Acyclovir, Microcapsules

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