Pharmaceutical Characterization of Cassia tora of Seed Mucilage in Tablet Formulations 

By Sudarshan Singh, Dr Sunil B Bothara, Sangeeta Singh, Roshan D. Patel, Naveen K. Mahobia 

ABSTRACT

Cassia tora (Cassia obstusifolia L) is a common herbaceous annual occurring as a weed throughout India and belongs to the family of Caesalpiniaceae. Seeds of plant contain gluco-mannose hence attempt to evaluate the seeds for suitability as tablet binder is considered and the present investigation repots the isolation of mucilage of Cassia tora seed. The DSC and FTIR thermograms of drug and gum indicated no chemical interaction. Phytochemical characteristics of mucilage such as carbohydrate, protein, fat and flavanoids etc. were studied. Physiochemical characteristics of mucilage such as solubility, swelling index, loss on drying, viscosity, hydration capacity, powder porosity, microbiological properties and pH were studied. The mucilage was evaluated for its granulating and binding properties in compressed tablet using Zidovudine as model drug. Mucilage was used in four different concentrations i.e. 2.0, 4.0, 6.0 and 8.0% w/v. The granules were prepared by wet granulation process. The prepared granules were evaluated for percentage of fines, average particle size, compressibility index and flow properties. The properties were compared with Guar gum which was used as standard binder at 8.0% w/v concentration. The tablet were prepared and evaluated for content uniformity, hardness, friability, disintegration time and in vitro dissolution profile. The tablets had good physiochemical properties and the drug release was more than 85% within 4 hour. It was observed that increasing the concentration of mucilage increases hardness and decreases the disintegration time. All the formulations (F1, F2, F3, F4 and F5) were subjected to stability studies for three months at 25°C/60% RH, 30°C/65% RH and 40°C/75% RH as per ICH guidelines all four formulation showed stability with respect to release pattern and other parameters which confirm the use of mucilage as excipient. 

Keywords: Cassia tora, Mucilage, Hydrogel, Binder.

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