Simultaneous Estimation of Olmesartan Medoxomil and Amlodipine Besylate in Solid Dosage Form by UV Spectrophotometry 

By Tripti Sharma, Neelam Mishra, Sudam C.Si, D. G.Shankar 

ABSTRACT

Olmesartan medoxomil is an ACE inhibitor and Amlodipine besylate is calcium –  channel blocker. Simple, precise, rapid and selective simultaneous equation and Q- analysis UV spectrophotometric methods have been developed for simultaneous determination of Olmesartan medoxomil and Amlodipine besylate from tablet dosage forms. The methods involve solving of simultaneous equations and Q-value analysis based on measurement of absorptivity at 256.8nm, 239nm, 235.6nm respectively. Linearity lies between 5-30µg/ml for both the drugs Olmesartan medoxomil and Amlodipine besylate. 

Keywords: Olmesartan medoxomil, Amlodipine besylate, Simultaneous Equation method, Absorbance Ratio method.

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