Preparation and characterization of spherical agglomerates of Ibuprofen by solvent change method 

ByP. K. Kulkarni, Mudit Dixit, Ashwini G Kini and M.Karthik  

ABSTRACT

Ibuprofen, an anti-inflammatory drug, exhibits poor water solubility and flow properties. Spherical agglomerates were prepared by solvent change method. Solvent composition for spherical agglomeration was determined by constructing ternary diagram. Crystallization medium used for spherical agglomerates of ibuprofen consisted of iso propyl alcohol(good solvent); water (poor solvent); iso propyl acetate (bridging liquid) in the ratio of 30:100:9, respectively. Spherical agglomerates were characterized by differential scanning calorimetry, Infrared spectroscopy, X-ray diffractometry and scanning electron microscopy. Micromeritic and dissolution behavior studies were carried out. Process variables such as amount of bridging liquid, stirring time and duration of stirring were optimized. Dissolution profile of the spherical agglomerates was compared with commercial sample and recrystallized sample. Spherical agglomerates exhibited decreased crystallinity and improved micromeritic properties. The dissolution of the spherical agglomerates was improved compared with commercial sample. 

Key Words: spherical agglomerates, Ibuprofen, dissolution.

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