Formulation and Evaluation of Buccoadhesive Films of Losartan Potassium
By Umesh. D. Shivhare, Parag. D. Bodkhe, Kishor P.Bhusari, Vijay B. Mathur
Buccoadhesive buccal delivery systems for losartan potassium in the form of buccal films were developed and characterized for improving bioavailability. The films were formulated by solvent casting method using different bioadhesive polymers like HPMC, Eudragit RS100, Eudragit RL100 and Ethylcellulose with glycerol as plasticizer. The films were characterized on the basis of their physical characteristics, bioadhesive performance and other parameters. In vitro studies revealed that release rate of losartan potassium was higher from films containing ratio of HPMC and Eudragit RL100 in proportion of 2:2. Drug diffusion from buccal films showed Peppas model kinetics and release mechanism was non-fickian. All the films exhibited sufficient in vitro bioadhesion strength. Promising formulation was further studied for temperature dependant stability studies. The results indicated that, therapeutic level of losartan potassium can be achieved using this buccoadhesive formulation.
Keywords: Buccal film, losartan potassium, bioavailability, bioadhesive strength
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