Synthesis of some new chalcones, flavones and screening for their antimicrobial activity 

By Vanita A Navale, S.B. Zangade, R.S. Shinde and S.G. Patil 


New chalcones (3a-k) were synthesized from substituted 2-hydroxy acetophenones and 2- benzyloxy, 3-benzyloxy-4-methoxy, 4-benzyloxy-3-methoxy benzaldehyde via claisen-schmidt condensation. Further these chalcones converted into corresponding flavones (4a-k) by oxidative cyclization of chalcones using DMSO-I2. The structure of synthesized compound was confirmed by elemental analysis and spectral data. The newly synthesized compounds were screened for antimicrobial activity against E-coli, S. Typhi, Staph. aureus, and Aspergillus niger  

Keywords: Hydroxyacetophenones, Aldehydes, 2-Hydroxychalcones, Flavones and antimicrobial activity.

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