Formulation and Evaluation of Solid binary systems of an Antipsychotic Drug by Using a modified Carrier
By N.L Prasanthi, N. Rama Rao, S.S.Manikiran
The aim of the study was to formulate and evaluate solid binary systems of the poorly water-soluble novel antipsychotic drug ziprasidone hydrochloride. The solid binary systems were prepared by using a new carrier (modified starch such as starch phosphate) for improving the dissolution properties. Starch phosphate was prepared by a reported method. The solid binary systems were prepared by kneading method in different drug to carrier molar ratios (1:1, 1:3, 1:9 and 1:19). Evaluation of the solid binary system was performed using dissolution studies, Differential thermal analysis, Infrared Spectroscopy and X-ray powder diffraction studies. All the solid binary systems showed dissolution improvement when compare to pure drug and physical mixture to varying degrees, binary systems prepared by kneading method in 1:9 drug to carrier ratio exhibited the highest drug release. Mathematical modeling of in vitro dissolution data indicated the best fitting with Korsemeyer-Peppas model and the drug release kinetics primarily as Fickian diffusion.
Key words: Anti psychotic drug, starch phosphate, solid binary systems, kneading method, mathematical modeling.
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