Synthesis and antimicrobial activity of some novel thiazolidinone derivatives 

By Vilas Shelar, Ravi Telkar, C.H.S. Venkataramana 


Ethylchloroacetate and hydrazine hydrate were reacted with substituted aldehydes to get the corresponding substituted N-benzylidine-2-chloro acetohydrazides, which were further condensed with succinimide to get corresponding subsituted N-benzylidine-2-(2,5-dioxo pyrrolidin-1-yl) acetohydrazides. These compounds were cyclized with thioglycollic acid to get the corresponding thiazolidinone derivatives, which have been evaluated for their antimicrobial activity.  

Keywords: Thiazolidinone derivatives, N-benzylidine-2-chloro acetohydrazides, N-benzylidine-2-(2,5-dioxo pyrrolidin-1-yl)acetohydrazides, Antimicrobial activity.

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