Synthesis and antimicrobial activity of some novel thiazolidinone derivatives 

By Vilas Shelar, Ravi Telkar, C.H.S. Venkataramana 

ABSTRACT

Ethylchloroacetate and hydrazine hydrate were reacted with substituted aldehydes to get the corresponding substituted N-benzylidine-2-chloro acetohydrazides, which were further condensed with succinimide to get corresponding subsituted N-benzylidine-2-(2,5-dioxo pyrrolidin-1-yl) acetohydrazides. These compounds were cyclized with thioglycollic acid to get the corresponding thiazolidinone derivatives, which have been evaluated for their antimicrobial activity.  

Keywords: Thiazolidinone derivatives, N-benzylidine-2-chloro acetohydrazides, N-benzylidine-2-(2,5-dioxo pyrrolidin-1-yl)acetohydrazides, Antimicrobial activity.

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