Formulation and invitro evaluation of sustained release matrix tablets of anti-hypertensive drug Propranolol hydrochloride
By Shantveer V. Salger, Lingaraj S. Danki, Abdul Sayeed , Shivanand Hiremath
This study presents the results of in vitro dissolution of sustained release propranolol hydrochloride (PPN) matrix tablets using hydroxypropyl methyl cellulose K100M as a rate retarding polymer. The effects of the proportion of the polymer and the influence of excipient like microcrystalline cellulose on the release rate of drug was investigated. The results of the present study point out that the rate of propranolol hydrochloride release from HPMC K100M matrices are mainly controlled by the drug –HPMC ratio. When the influence of excipients on the release of drug was examined, the excipient microcrystalline cellulose enhanced the release rate of propranolol hydrochlroid.
Keywords: Hydrophilic matrix tablet, HPMC, Sustained-release, propranolol hydrochloride, Formulation
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