Formulation and evaluation of transdermal patches of curcumin

By Saraswathi R,  Krishnan.P.N, Dilip.C, Shabir Ali T.K.  

ABSTRACT

An attempt was made to formulate and evaluate the curcumin transdermal drug delivery system.

Preformulation studies on the drug curcumin were done which included description, solubility and compatibility studies. The transdermal patches were made which were of matrix diffusion control system. Solvent casting technique was used to prepare the transdermal patches. Three formulations were made with 20mg of curcumin and by using polymers namely hydoxy propyl methyl cellulose, ethyl cellulose at various ratios and the yield was noted. Curcumin was physically examined for color and odour. Solubility was determined in water, phosphate buffer pH -7.4, Ethanol, DMSO and Tetra hydro furan.  Interaction of drug and polymer was confirmed by UV – Visible interaction and FTIR studies. Based on this further evaluation was carried out.Invitro drug diffusion stuy was also carried out using modified Franz diffusion cell. Transdermal patches were evaluated for the weight, thickness, percentage moisture uptake, percentage flatness, folding endurance, water vapor transmission rate, and in-vitro release studies. This was done for three formulations F1, F2, F3. It was found that formulation F1 showed the best compatibility on the basis of all tests performed. 

Key words: Transdermal patches, Curcumin, Formulation.

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