Biologically active azoles: Synthesis, characterization and antimicrobial activity of some 1-substituted imidazoles

By Baskar Lakshmanan, Papiya Mitra Mazumder, Dinakar Sasmal and Swastika Ganguly 

ABSTRACT


A few 1-substituted imidazoles 1(a-d) and 2(a-d) have been synthesized and characterized on the basis of elemental analysis, FT-IR, 1H-NMR and DART-MS spectral data. The synthesized compounds were screened for their In vitro growth inhibiting activity against different strains of bacteria and fungi viz., Staphylococcus aureus, Bacillus subtilis, Streptococcus faecalis, Escherichia coli, Pseudomonas aeruginosa, Salmonella typhi, Candida albicans, Aspergillus niger and Penicillium chrysogenum (10 and 50µg/ml) and the results were compared with the standard antibiotic Ciprofloxacin and ketoconazole (10µg/ml) using agar diffusion technique.

Key words: 1-Substituted imidazoles, phenacyl bromides, antimicrobial evaluation, agar well diffusion method.

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