The anti-snake venom activity of the leaves of Symplocos cochinchinensis (Lour.) S. Moore ssp. laurina  (Symplocaceae)

By Lakshmi K.S and Vadivu R

ABSTRACT


The invitro and invivo anti-snake venom activities of various extracts of the leaves of Symplocos cochinchinensis(Lour.) S. Moore ssp. laurina (Symplocaceae) were studied against Russell’s viper venom. The In vitro study was carried out by the inhibition of the In vitro Human RBC lysis and the In vivo study was carried out by using Swiss albino mice in modifying the lethal effect of the test dose of the Russell’s viper venom. In invivo model the effectiveness of the extract was evaluated by oral administration of two different doses (200 and 400mg/kg) of the methanolic extract of the leaves of Symplocos cochinchinensis 5 minutes prior to the injection of the venom. The extract markedly decreased the percentage of mortality in venom induced toxicity in mice at the dose of 400mg/kg b.w which indicates the significant anti-snake venom activity of the plant there by justifying its use in the indigenous system of medicine.

Key words: Invitro and invivo anti-snake venom activity, Symplocos cochinchinensis, methanolic extract, Russell’s viper venom.

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