Synthesis, characterization and antimicrobial activity of novel benzimidazole molecule

By Shabista Khan, F. B. Bux and Arun Singh

ABSTRACT


The reaction between benzimidazole with N-[4-(2-chloroacetyl)phenyl]acetamide affords  N-[4-(2-(1H-benzimidazol-1-yl) acetyl] phenyl acetamide,which upon hydrolysis yield 1-(4-aminophenyl)-2-(1H-benzimidazol-1-yl)ethanone.  The  Diazotion of 1-(4-aminophenyl)-2-(1H-benzimidazol-1-yl)ethanone couple with salicylic acid,they afford the ligand compound and named  as 5-([4-(2-(1H-benzimidazol-1-yl)acetyl)phenyl]diazenyl)-2-hydroxybenzoic acid(SA-BI).  The transition metal complexes of Cu2+, Co2+ ,Ni2+, Mn2+ and Zn2+ of SA-BI have been prepared and characterized by elemental analyses, spectral studies, magnetic moment determination, molar conductivity measurement and microbicidal activity.

Key words: Benzimidazole, salicylic acid, metal chelates, spectral studies, magnetic moment, antibacterial and antifungal activity.

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