Synthesis, characterization and evaluation of effect of chemical modification of hydroxypropyl methylcellulose on drug release


By Nagesh H. Aloorkar and Manish S. Bhatia


A novel polymer, hydroxypropyl methylcellulose (HPMC) chemically modified by reacting with maleic anhydride was synthesized. FTIR and NMR spectroscopy, DSC analysis and determination of physicochemical property like viscosity were used to confirm the formation of novel polymer. Ibuprofen, paracetamol and diclofenac sodium matrix tablets were prepared employing HPMC and novel modified HPMC to evaluate the effect of chemical modification on drug release properties of HPMC. Drug release was found to be increased from modified HPMC matrices and unlike HPMC, release mechanism was found to be due to polymer erosion. Thus, it can be concluded that biocompatible chemical modifications of polymers could make better options accessible for specific formulation objectives.

Key words: HPMC, chemically modified HPMC, drug release, matrix tablets, polymer erosion.

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