hepatoprotective potential of aqueous extract of Ganoderma lucidum   against carbon tetrachloride intoxication in rats

By O. M. Oluba, E. C. Onyeneke, G. C. Ojieh, B. O. Idonije and T. I. Ojiezeh

ABSTRACT


The present study was undertaken to investigate the hepatoprotective effect and antioxidant property of aqueous extract from Ganoderma lucidum  (GLE) on carbon tetrachloride (CCl4)-induced hepatotoxicity in rats. Treatment with 200 mg/kg body weight of GLE for six consecutive weeks prior to the administration of CCl4 (1.5 ml/kg in olive oil, 20%) significantly prevented the increased serum alanine aminotransferase (ALT) and aspartate aminotransferase (AST) activities, gamma glutamyltranspeptidase (?-GT) and serum molodialdehyde (MDA) levels. The extract also induced the up-regulation of hepatic antioxidant enzymes namely superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GSH-Px) and glutathione reductase (GSSG-Rx) activities. In addition, pretreatment with GLE prior to CCl4 intoxication drastically reduced incidences of ballooning degeneration, necrosis and portal traditis which are direct consequence of CCl4-induced damage. These results attest to the hepatoprotective and antioxidant potentials of aqueous extract of G. lucidum in rats.   

Key words: Ganoderma lucidum, toxicant, hepatoprotection, antioxidants, oxidative stress

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