Electronic evaluation by sensing device

By Mayank Patel, Sheetal Malke, Supriya Shidhaye and Vilasrao Kadam

ABSTRACT


Many active pharmaceutical ingredients usually associated with bitterness, can impart an unpleasant taste or odor. To produce a desirable oral drug product, especially if destined for pediatric use, development efforts focus on masking the unpleasant taste or odor, often by adding flavoring or sweetening agents to the formulation. The formulations organoleptic properties taste, odor, mouth-feel and appearance are of considerable importance in differentiating products in the market and can ultimately determine the success of a product. Organoleptic analysis of such prototype products is commonly performed by human taste panels. However, in an effort to eliminate human testing due to the safety risks and since it is time-consuming and expensive, alternative analytical means are being sought. The electronic tongue or electronic nose is such a system for automatic analysis and recognition of liquids or gases, including arrays of non-specific sensors, data collectors and data analysis tools. Electronic tongues are used for liquid samples analysis, whereas electronic noses for gases. The result can be the identification of the sample, an estimation of its concentration or its characteristic properties. The novel electronic tongue technology is being utilized by the food/beverage and pharmaceutical industries to evaluate product taste characteristics. The electronic-nose device may provide testing of odors and also provide physicians with a quicker and more accurate diagnostic tool for a number of diseases. Also it can be used for detection and identification of certain chemical compounds in exhaled air and excreted urine or body fluids related to specific metabolic conditions, certain skin diseases, or bacterial infections.

 

Key words: Bitter, mouth feel, taste masking, human testing, electronic tongue, electronic nose.

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