Intragastric floating drug delivery of Ambroxol Hydrochloride using pectin and carbonate salts

By Swati C. Jagdale, Santosh S. Padekar, Ajay S. Bhadoriya, Swapnil A. Ghorpade and Bhanudas S. Kuchekar

ABSTRACT


The purpose of this work was to develop intragastric floating drug delivery by a means of calcium pectinate gel (CaPG) and zinc pectinate gel (ZnPG) beads. The CaPG and ZnPG beads containing carbonate salt, as a gas-forming agent, were prepared by dispersing carbonate salt in pectin solution and then extruding into either neutral or acidified solution of calcium chloride and zinc acetate respectively. The effect of factors such as type of carbonates, percentage of carbonates, gelation medium, drug loading, on floating and release properties was investigated. To overcome limitations of various approaches for imparting buoyancy, porous beads were prepared by incorporation of carbonate salts into pectin solution. Acidity of gelation medium increased the pores in the structure of beads containing calcium carbonate and zinc acetate. This is due to carbon dioxide generated from reaction of carbonate salts with acid. The highly porous beads prepared with carbonate salts and acidified gelation medium showed a good floating ability with fast drug release.

Key words: Pectin; calcium pectinate; zinc pectinate; floating drug delivery; Ambroxol hydrochloride

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