Preparation and evaluation of floating multiparticulate drug delivery system

By Parag A. Kulkarni, Santosh B. Jawale, Mahendre K. Jaiswal, Abhijit D. Kulkarni, Satish V. Shirolkar and Pramod V. Kasture

ABSTRACT     


The goal of the present study was to develop a floating mutiparticulate drug delivery system based on gas formation technique, in order to prolong the gastric residence time and increase the overall bioavailability of the drug from dosage form. The system consists of the core pellets which are coated with three different layers, inner layer of drug, middle layer of effervescent material alongwith  binder polymer (sodium bicarbonate) and an outermost of gas-entrapped sustained release polymeric membrane (Eudragit® RSPO: RLPO). The time to float increased as the coating level of gas-entrapped polymeric membrane increased. The optimum system could float completely within 2 min. and maintained the buoyancy over a period of 24 h. The drug release was sustained and linear with the square root of time. Increasing coating level of gas-entrapped polymeric membrane decreased the drug release. Both the rapid floating and the sustained release properties were achieved in the floating multiparticulate drug delivery system developed in this current study.

Key words: Floating, multiparticulate, effervescent, coating, eudragit.

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