An efficient synthesis of 1, 2, 4-triazine derivatives and their In vitro antimicrobial activity

By Bhaskar S. Dawane, Shuddhodan N. Kadam and Baseer M. Shaikh


A simple and efficient synthesis of 1, 2, 4- triazine derivatives is described by the condensation of substituted 4-(2-chloro-quinoline-3yl methylene)-2-[phenyl-4H-oxazol-5-one and phenyl hydrazine an equimolar sodium acetate and acetic acid as a solvent. The newly synthesized compounds were evaluated for their antimicrobial activity.  

Key words: Substituted 4-(2-chloro-quinoline-3yl methylene)-2-[phenyl-4H-oxazol-5-one, phenyl hydrazine, triazine derivatives, antimicrobial activity.

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