Synthesis and study of antimicrobial agent 3-(3-substituted-1H-indon-1-yl)-2-phenylquinoline-4-carboxylic acid

By Anees A. Siddiqi, Jaya Dwivedi, Swapnil Sharma and Rajani  Chauhan

ABSTRACT


Present work describes the Synthesis of 3-(3-substituted-1H-indon-1-yl)-2-phenylquinoline-4-carboxylic acid derivatives by Pfitzinger reaction of isatin with 2(1H-indol-1-yl)-1-phenyl ethanone and 1-phenyl-2-[-3-(substituted)-1H-indole-1-yl] ethanone. The structures of all the compounds are established by elemental analysis, IR, 1H NMR and Mass spectral data. These compounds possess excellent antimicrobial activity against bacteria and fungi.

 

Key words:  Chalcone, Schiff’s base chalcone, quinazoline derivatives, antimicrobial activities.

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