Comparative efficiency of metal phosphates as a protomer in multi-component condensation reaction

By Dhanashri K. Shete, Sharda S. Surve, Snehal B. Patil, Sarika B. Narade, Kiran S. Patil and Yogesh V. Pore


This work was aimed to investigate the efficiency of various metal phosphates as a protomer in the synthesis of multi-component condensation reaction. The multi-component reaction employed in this work was a ternary condensation between urea/thiouea, an aldehyde and 1,3-dicorbonyl compound. The metal phosphates utilized as a protomer in condensation reaction were mono and dibasic phosphates of sodium and potassium metals (NaH2PO4, KH2PO4 and K2HPO4). The efficiency of these phosphates were investigated in a common solvent; glacial acetic acid which is a very cheap and cost-effective. Six different condensation products (4a-4f) were obtained by using different aldehydes and 1,3-dicorbonyl compound to ensure reproducibility of the reaction. The structures of all compounds were confirmed on the basis of spectral data (IR and 1HNMR). Among the metal phosphates used, KH2PO4­ demonstrated excellent efficiency as a protomer in terms of excellent yields and purity as compared to other phosphates.    


Key Words : Metal phosphates, Protomer, Multi-component reaction, Ternary condensation, Efficiency.


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