Evaluation of wound healing activity of Ichnocarpus frutescens root

By A. Pandurangan, R.L Khosa  and S.Hemalatha


Abstract


The methanol extract of Ichnocarpus frutescens R. Br (Apocynaceae) roots were investigated for the evaluation of their wound healing potential on different experimental models of wounds in rats. The methanol extract of roots (MEIF), in the form of an ointment with two different concentrations (1 % and 2 % w/w ointment of root extract in simple ointment base) was evaluated for wound healing potential in an excision wound model and an incision wound model in rats. Both concentrations of the methanol extract ointment showed significant responses in both the wound types tested when compared with the control group. The effect produced by the extract ointment, in terms of wound contracting ability, wound closure time, regeneration of tissues at wound site, tensile strength of the wound and histopathological characteristics were comparable to those of a standard drug framycetin sulphate cream.

 

Key Words : Ichnocarpus frutescens; Wound healing; Excision wound; Incision wound.

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