Acyclovir Loaded Chitosan Nanoparticles for Ocular Delivery

By Selvaraj. S, Saravanakumar. N, Karthikeyan. J, Deborah Evangeline. D, Lathamary. Rajendran N. N


The topical application of acyclovir as eye ointment remains a concern for effective management of various ocular viral diseases owing to poor ocular drug bioavailability. Hence the present study was aimed to develop and evaluate nanosphere colloidal suspension containing acyclovir as potential ophthalmic drug delivery system. The acyclovir loaded chitosan  nanoparticles  were prepared by ionic gelation of chitosan with tripolyphosphate anions (TPP). The nanoparticles were characterised by Scanning Electron Microcopy (SEM), Zeta potential analyser, Differential Scanning Calorimetry (DSC) and Fourier Transform InfraRed (FTIR) Spectroscopy. All the prepared formulations resulted in nano range size partricles (200 - 495 nm) and displayed spherical smooth morphology with Zeta potential (+36.7 - +42.3 mV). The encapsulation efficiency and loading capacity were 56% - 80% and 10% - 25% respectively. The acyclovir loaded chitosan nanoparticles displayed crystallinity than acyclovir. The invitro diffusion profile of acyclovir from the nanoparticles showed a sustained release of the drug over a period of 24 hrs. Kinetic release profiles of acyclovir from nanoparticles appeared to fit best with Higuchi model with zero order and the non- Fickian diffusion was superior phenomenon. Thus the results suggest that acyclovir loaded chitosan nanoparticle suspension appears promising for effective management of ocular viral infections.


Key Words : Acyclovir, Chitosan, Nanoparticles, Ocular delivery, Ionic gelation method.

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