Incidence of Adverse Drug Reactions in a Tertiary Care Hospital:  A Systematic Review and Meta-Analysis Of Prospective Studies

By Mohammed Misbah Hussain, Kundlik Girhepunje, Ranju Pal, Shahina Sugra Siddiqua


To study the incidence of adverse drug reactions in a tertiary care hospital and to determine the drugs which cause adverse drug reactions, the age group and sex commonly affected in outpatients and inpatients. A systematic review of studies on ADRs in hospitalized patients, inpatients and outpatients, on ADRs causing hospital admissions were performed. Studies were identified through a search of the MEDLINE and EMBASE databases. The inclusion criteria required that the population was not selected for particular conditions or drug exposure and prospective monitoring was used for identifying ADRs. Data were analysed by a random-effects model. A total number of 50 patients with adverse drug reactions (ADRs) were reported in the present study. Maximum number of adverse drug reactions were observed with NSAIDs. Out of 50 patients, 16 developed ADRs with different NSAIDs, which were 32%. 26% of patients had adverse drug reaction with antibiotics, which included 13 patients. 4 cases with anti-tubercular drug (8%), 3 cases with anticancer drugs (6%), one case each with anti-covulsant, antiviral, anti-diabetic and antihypertensive drug (2% each), and 10 patients developed ADRs with herbal drugs which was 20%. The results shown that ADRs in patients are a significant public health issue. The accuracy of prescription reporting as well as clinical information from studies was a rarity, making it difficult for healthcare practitioners to implement evidence based preventive strategies. Further, methodologically sound drug surveillance studies are necessary for an effective promotion of a safer use of drugs.


Key Words : adverse drug reactions, patient, meta-analysis, prospective studies, systematic review.

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