Analgesic Activity of Various Leaf Extracts of Saraca indica Linn

By Angad Verma, Goutam Kr. Jana, Raja Chakraborty, Saikat Sen, Sandeep Sachan, Ashutosh Mishra


Abstract

The nature has provided abundant plant wealth which possesses several medicinal values. It is necessity to explore their pharmacological properties to ascertain their therapeutic properties. Saraca indica is an important indigenous plant with a lot of traditional importance. The present study is an attempt to explore the analgesic activity of petroleum ether, chloroform, methanol and water of whole part of this plant. The analgesic activity of above extracts was evaluated by using tail immersion method and formaline induced pain method in albino mice. Analgesic activity of petroleum ether (PSI), chloroform (CSI), methanol (MSI) and water (WSI) extracts were investigated at a dose of 200 and 400 mg/kg. Extracts produce dose dependent analgesic activity. Metahnol extract at a dose of 400 mg/kg produced highest activity. MSI produced 52.64 and 43.30% inhibition of formalin induced pain response in first and second phase respectively, whereas standard drug pentazocine (10 mg/kg) produced 61.3 and 52.38% pain response inhibition.  Extracts also produced significant analgesic activity in tail immersion method also and produced highest activity after 90 min like that of standard drug. The result tends to suggest that the extracts of Saraca indica leave posses analgesic activity.

 

Key Words : Saraca indica, analgesic activity, methanol extract, formalin, tail immersion.

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