Preparation and Evaluation of Fast Disintegrating Tablets of Dicyclomine HCl

By Sunita Kumari, Sharad Visht, Pramod kumar Sharma


Abstract

The purpose of the present research is to prepare Fast Disintegrating Tablets of Dicyclomine Hydrochloride and evaluate the effect of super-disintegrants on disintegration behavior. Fast Disintegrating tablets of Dicyclomine Hydrochloride were prepared using sodium starch glycolate together with Micro crystalline cellulose as superdisintegrants. Mannitol was used as diluents and saccharin sodium was used as sweetener for taste masking. All the formulations showed weight variation less then 103.89 ±0.41 with in-vitro disintegration time less than 40 seconds. The results revealed that the tablets bear a good dissolution profile. The drug content of all the formulations was within the acceptable limits of the United States Pharmacopoeia XXVII.
This work will help in understanding the effect of superdisintegrants on disintegration behaviour of tablet, dissolution, absorption and finally the bioavailability of drug. The present study demonstrated potentials for rapid disintegration/dissolution, absorption, improved bioavailability, effective therapy and improved patient compliance.

 

Key Words : Mouth Disintegrating tablet, Dicyclomine HCl, Superdisintegrant, Direct compression.

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