Isolation and Characterization of Mucilage from Leaves of Cinnamomum Tamala Nees and Evaluation of Binding Property
By Shivani Singh, Satyam Gangwar, Garima Garg, Vipin Garg, P.K.Sharma
In the present study the mucilage obtained from bay leaves [cinnamomum tamala Nees (lauraceae)] was used as binder for the formulation of paracetamol tablets. The physicochemical characterization of mucilage was done and the % swelling capacity of mucilage was found to be 33.2%. Mucilage was also characterized by FTIR spectroscopy as well as qualitative phytochemical screening. Mucilage showed the presence of tannins and sugars. Five batches of paracetamol tablets were prepared using three different concentrations (5, 10 & 15%) of mucilage, PVP & starch as binder. From in-vitro release data it was observed that bay leaves mucilage posses good binding property similar to commercial pharmaceutical binders in the concentration range between 10 to 15%. Tablets were also evaluated for hardness and friability and the friability values for all the tablets was found to be less than 1% and thus showing good binding property.
Key Words : Bay leaf, Cinnamomum tamala, binder, mucilage, paracetamol.
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