Evaluation of antidiarrhoeal property of the hydroalcoholic extract of roots of Calotropis gigantea R.Br. on Caster-induced diarrhoea in rats

By Bhanu Pratap, Rajeev Kumar, Devnath Tiwari, Sanjay Yadav, and Satyawan Singh


Diarrhoea (Greek and Latin: dia, through and rheein: to flow or run) is characterized by increased frequency of bowel movement, wet stool and abdominal pain. Diarrhoea is a major health problem especially for children under the age of 5 years. Worldwide distribution of diarrhoea accounts for more than 5-8 million deaths each year in infants. According to W.H.O. estimates for 1998, about 7.1 million deaths were caused by diarrhoea. The incidence of diarrhoeal diseases still remains high despite the efforts of many governments and international organisations to curb it. Calotropis gigantea Linn. (Asclepiadaceae) is a glabrous or hoary, laticiferous shrubs or small trees, commonly known as Swallow-Wort or Milkweed or wasteland weed or Ak or Boro Akanda. In this study, we examined the Antidiarrhoeal property of the hydroalcoholic extract of root of C. gigantea on Caster-induced diarrhoea in rats. From this study, the use of the root of C. gigantea in traditional medicine as a non-specific antidiarrhoeal agent has been justified. Further studies are, however, needed to establish the safety of the extract and to possibly isolate the active principle responsible for the observed effects.



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