Formulation and Evaluation of Different Polymer based Periodontal Film of Ofloxacin

By Navaneet Singh, Rishabha Malviya, Mayank Bansal, Pramod Kumar Sharma


Abstract

In present investigation periodontal films of ofloxacin was formulated using different polymers. Simple casting method was used to prepared films of chitosan, carbopol 934, polyvinyl pyrrolidine K30 and hydroxy propyl methyl cellulose K4M. In different formulations glycerine was used as plasticizer. Prepared films were evaluated for thickness uniformity, weight uniformity, tensile strength, folding endurance, moisture loss, content uniformity and drug release. Results obtained from different studies were found within acceptable limits. Film containing chitosan showed maximum tensile strength over other batches. Films prepared using Carbopol 934 showed maximum drug release (98.35) over a long period of time. The findings of the results easily predict the fact that chitosan, carbopol 934, polyvinyl pyrrolidone K30 and hydroxy propyl methyl cellulose K4M can be used to prepare film for the treatment of peridontal disease.

 

Key Words : periodontal film, ofloxacin, periodontitis.

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