Synthesis and biological activity of 3-(2-(5-Benzoyl-1h-Benzo[d] Imidazol-1-Yl) Acetyl)-5-Benzylidene-2-Alkylthiazolidin-4-One

By Arun Singh, Deepak Kumar and F.B.Bux


Abstract

2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) acetohydrazide (3) undergoes facile condensation with aromatic aldehydes to afford the corresponding 2-(5-benzoyl-1H-benzo[d]imidazol-1-yl)-N'-alkylidene aceto hydrazide (4a-h) in good yields. Cyclocondensation of compounds (4a-h) with thioglycolic acid yields   3-(2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) acetyl)-2-alkylthiazolidin-4-one (5a-h). These (5a-h) compounds are for the reacted with benzaldehyde in the presence of sodium ethanolate affords, giving 3-(2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) acetyl)-5-benzylidene-2-alkylthiazolidin-4-one (6a-h). The structures of these compounds were established on the basis of analytical and spectral data. All the newly synthesized compounds were evaluated for their antibacterial and antifungal activities.

 

Key Words : 2-(5-benzoyl-1H-benzo[d]imidazol-1-yl) aceto hydrazide, thiazolidine, antibacterial activity.

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