formulation and in vitro evaluation of sustained release microspheres of Metoprolol Tartrate Loaded Eudragit-RS100

By Karthikeyan. J, S. Janardhan, N. Saravanakumar, S. Selvaraj, R. Sivasakthi, R. Mennakumari


The objective of the present study was to microencapsulate the Anti-Hypertensive drug (treatment of several disease of Cardio Vascular System, especially Hypertension.) Metoprolol Tartarte to provide Sustain Release and maintain constant the plasma drug concentration and reduce the frequent administration and improve the Patient compliance, unwanted side effects and Dose dumping. Metoprolol was microencapsulated with Eudragit-RS100 using solvent evaporation techniques. The effect of different 6 Formulation variables including the drug polymer ratio. Metoprolol Microspheres was subjected to micrometritic properties including Angle of Repose, Bulk density, Carr’s index, Haugner’s ratio and Particle size determination. Metoprolol Microspheres was subjected to Drug Loading, invitro drug release as well as for Scanning electron microscope and kinetic drug release.


Key Words : Metoprolol Tartarte, Eudragit RS100, Solvent Evaporation, Microspheres, Drug loading, Release kinetics.

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