Evaluation of Antibacterial Activity of Some Substituted Phenyl Benzaldimine Derivatives

By Kumar Saurav Dey, Surajit Kumar Ghosh


Abstract

A series of Phenylbenzaldimine derivatives were derived from 3-chloro-4-fluoroaniline as the central molecule with different substituted aromatic benzaldehydes as the side chain. Their structures have been characterized by IR, 1H -NMR, 13C-NMR, Mass spectra in addition to the elemental analysis. The antibacterial activity was studied against Bacillus subtilis, Staphylococcus aureus, Pseudomonas aeruginosa and Escherichia coli .These strains were procured from Department of Microbiology, Assam Medical College, Dibrugarh. The determination of the antibacterial activity was done using the disc diffusion method and MIC was determined by broth dilution method.   The antibacterial activity was evaluated in polar solvent, Dimethyl sulfoxide (DMSO).

 

Key Words : Phenylbenzaldimine derivatives, Antibacterial activity.

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