Industry feasible method to improve solubility of Piroxicam with Crospovidone: Preparation, Characterization and tableting consideration

By Dinesh Kumar Sharma, Vipin Bihari Gupta and Suresh Purohit


Abstract

Nearly 30-45 % of new seeds discovered by recent techniques suffer from poor aqueous solubility. Various techniques, used to enhance the aqueous solubility, are reported to produce many disadvantages. Solid dispersion technique is widely used to enhance aqueous solubility.   In spite of consciousness in solid dispersions technique, investigators have been able to provide only few numbers of carriers to the industry. Moreover these carriers are reported to produce many disadvantages. Therefore, definitely there is need to explore such new carriers. Current study was undertaken to explore suitability of one such carrier crospovidone as solubility enhancer. Physical mixtures, kneading mixtures and solid dispersions were prepared by solvent evaporation technique using piroxicam as model drug. Kneading mixtures at drug carrier ratio of 1:7 produced maximum solubility. The resulting systems were subjected to solubility analysis and in vitro dissolution studies, flow properties, X-ray diffraction, Infrared Fourier Transform Spectroscopy (FTIR) and differential scanning calorimetry. Kneading mixtures at 1:7 ratio produced improved flow properties in comparison to pure piroxicam. The % drug dissolved after 5 minutes for PRX: CrosPVP KM 1:7 and pure piroxicam was 26.43 % and 11.49% respectively. 86.57 % of piroxicam was dissolved from PRX: CrosPVP KM 1:7 after 120 minutes. Kneading mixtures were successfully compressed in tablets having all post compression parameters within limit in comparison to tablets prepared using MCC or calcium phosphate as diluent. Lower energy required for dissolution due to change in crystal lattice is responsible for improvement in solubility of drug.  

 

Key Words : Piroxicam, Poorly water soluble drug, Dissolution, Flow properties

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