Development and validation of spectrophotometric methods for simultaneous estimation of Paracetamol and Meloxicam in pure and tablet dosage form

By Ramesh   Sawant, Rupali Joshi, Deepali Kawade and Varsha Sarode


Abstract

Two simple, accurate, economical and reproducible spectrophotometric methods for simultaneous estimation of paracetamol and meloxicam in pure and tablet dosage form have been developed. Method I is based on solving simultaneous equation. Paracetamol and meloxicam show absorbance maximums at 256 and 268.8 nm so absorbance was measured at the same wave lengths for the estimation of paracetamol and meloxicam. Method II is based on determination of Q-value. Absorbance was measured at 308 nm (Isobestic point) and 256 nm (?max of paracetamol). Both drugs obey the Beer Lambert's law in the concentration range of 5-30 µg /mL. Methods are validated according to ICH guidelines and can be adopted for the routine analysis of paracetamol and meloxicam in pure and tablet dosage form.

 

Key Words : paracetamol, meloxicam, simultaneous equation method, absorbance ratio method, validation

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