By Arunabha Mallik, Damodhar Goupale, Hemant Dhongade, Satish Nayak
In spite of tremendous advances in the chemical drug industry, the availability of substances capable of stimulating the process of wound repair is still limited. Moreover, the management of chronic wounds is another major problem due to the high cost of therapy and the presence of side effects. Since no studies were carried for wound healing activity of the oleo-gum resins obtained from Boswellia serrata an attempt has been made to evaluate the wound healing activity of the oleo-gum resins obtained from Boswellia serrata. For this purpose a cream was formulated using oleo-gum resins of Boswellia serrata and was applied topically on the excision wound surface as single dose in different percentages. Wound contraction and tensile strength measurements were used to evaluate the effect of Boswellia serrata oleo-gum resins on wound healing. The results obtained indicated that Boswellia serrata accelerates the wound healing process by decreasing the surface area of the wound and increasing the tensile strength. The greatest contraction was obtained at a single application of 15 % w/w of formulated cream. Measurements of tensile strength and healed area were in agreement. The results suggest that treatment with Boswellia serrata oleo-gum resin may have a beneficial influence on the various phases of wound healing like fibroplasias, collagen synthesis, and wound contraction, resulting in faster healing. In conclusion, the observations and results obtained in this study indicated that the Boswellia serrata oleo-gum resin significantly stimulated wound contraction. These findings could justify, role of this plant material in the management of wound healing.
Key Words : Boswellia serrata; Wound healing; Wound contraction; Tensile strength.
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