Hypoglycemic effect of Argyreia nervosa root extract in normal and Streptozotocin-diabetic rats

By Shiv Kumar, K. R. Alagawadi

Abstract

This study reports hypoglycemic effect of alcoholic extract of Argyreia nervosa roots (500 mg/kg body weight orally) in normal, glucose loaded and Streptozotocin (STZ) induced diabetic rats. The extract produced decrease in blood glucose level in normoglycaemic rats (82.6 + 2.6 vs 61.3 + 2.8 mg/dl at 6th hr). In oral glucose loaded rats, it reduced blood glucose levels from 118.4 + 5.4 to 96.4 + 4.2 mg/dl 2h after oral glucose load. When given orally for 7 days in STZ diabetic rats, it produced significant antihyperglycemic effect and also reversed the changes in total hemoglobin and glycosylated hemoglobin content.

 

Key Words : Argyreia nervosa, Blood glucose levels, Hypoglycemic effect, Streptozotocin.

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