Enhancement of solubility: A pharmaceutical overview

By Behera A. L., Sahoo S. K., Patil S. V.

 

Abstract

The study on solubility yields information about the structure and intermolecular forces of drugs. Use of the solubility characteristics in bioavailability, pharmacological action and solubility enhancement of various poorly soluble compounds is a challenging task for researchers and pharmaceutical scientists. General parameters affecting solubility are particle size, shape and surface area physicochemical properties of drugs, physical forms of drugs, solvents, pH of the medium, temperature and use of surfactants.

 

Key Words : Solubility, pH, temperature

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