Formulation and evaluation of Ciprofloxacin controlled release matrix tablets

By Prabu Moses, L. Subramanian, S. Palanichamy, S. Jeganath, A. Thanga Thirupathi

 

Abstract

The goal of this study was to formulate and evaluate ciprofloxacin controlled release matrix tablets. Ciprofloxacin controlled release tablets were prepared by wet granulation method using two polymers such as HPMC K 100M     (hydrophilic polymer) and guar gum (natural polymer) and with three polymer ratios (0.5, 1.0 and 1.5). The prepared granules were evaluated to preformulation studies such as angle of repose, bulk density, tapped density, bulkiness, compressibility index and hausners ratio. All the parameters shows that the granules having good flow properties. Then the formulated tablets were taken to evaluation studies such as hardness, weight variation, friability, drug content and thickness. All the parameters were within the acceptable limits. IR spectral analysis showed that there was no interaction between the drug and polymers. The in vitro release study was performed in phosphate buffer pH 7.4 at 278 nm. The in vitro release study showed that if the polymer ratio is increased, then the release of the drug is prolonged. HPMC K 100M shows a prolonged release when compared to guar gum.

 

Key Words : Ciprofloxacin, Controlled release, HPMC K100M, Guar gum.

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