Comparative evaluation of binders and disintegrants by formulating Lomefloxacin tablets

By K. P. R. Chowdary, Lingaraj S. Danki, Hiremath S. N.

 

Abstract

Lomefloxacin is a broad spectrum anti bacterial agent used in the treatment of respiratory tract and urinary tract infections. Major problem with this drug is its solubility in biological fluids after oral administration. Hence in the present work studies were undertaken on lomefloxacin tablets with an objective of evaluating the effect of formulation variables such as binding agents like gelatin, polyvinyl pyrrolidone, sucrose, starch paste, acacia, methyl cellulose and hydroxy propyl methyl cellulose and disintegrants like dry potato starch, sodium starch glycolate and micro crystalline cellulose on the dissolution rate of lomefloxacin. Among the seven binders added the tablets prepared with hydroxy propyl methyl cellulose, acacia and polyvinyl pyrrolidone were found to be superior with respect to disintegration and dissolution characteristics. Among the three disintegrants added the tablets prepared with dry potato starch are superior with respect to disintegration and dissolution. All formulations were subjected for kinetic analysis, results indicated that all the formulations prepared followed first order release kinetics, formulation containing lomefloxacin with dry potato starch as disintegrant and polyvinyl pyrrolidone as binder (T2) with a correlation co-efficient of 0.995. The marketed product showed 67.50% of drug release after 45 mins, where as T2 showed 95.62% of drug release. Formulation T2 was considered as better when compared to marketed product as far as dissolution efficiency D.E.30(%) and first order rate constant. Formulation T2 was also subjected for stability studies as per ICH guidelines and was found to be stable.

 

Key Words : Lomefloxacin, binders, disintegrating agents, tablets.

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