Synthesis, antibacterial and anticancer activities of some novel imidazoles

By Gyanendra Kumar Sharma, Suresh Kumar, Devender Pathak

 

Abstract

Amino group of thiazole moiety (1) have been treated with various aromatic aldehydes gave corresponding Schiff's bases (2-12). These Schiff's bases have been reacted with benzil and ammonium acetate (NH4OAc) to get corresponding novel imidazoles (2a-12a). Structures of all the newly synthesized compounds were confirmed by IR, 1H NMR, mass spectral data and elemental analysis. The synthesized compounds were evaluated for their antibacterial and short-term anticancer activity. All the synthesized substituted imidazoles have shown good antibacterial activity against gram negative bacterial strains Klebsiella pneumoniae and Escherichia coli. The synthesized imidazole derivative possessed significant cytotoxic activity against Dalton’s Lymphoma Ascites (DLA) and Ehrlich’s Ascites Carcinoma (EAC) cell lines.

 

Key Words : Thiazoles, imidazoles, antibacterial activity, anticancer activity.

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