Pharmacological evaluation of anti–inflammatory activity of Euphorbia hirta against carrageenan induced paw edema in rats


By Prabhat Das, Suman Mekap, Saumya Pani, Ranjan Sethi, Praveen Nayak



Euphorbia hirta is a well known plant of the herbal world, which gains the popularity due to its various pharmacological activities. The roots of plant Euphorbia hirta used as purgative and leaves and stems are reported to be cooked with cooked with pork and used as tonic. The present study was carried out to evaluate the effect of Euphorbia hirta (ethanolic and aqueous extract p.o.) on carragenan induced inflammation. The study was carried out on carragenan induced inflammation model by carragenan. Diclofenac Sodium 50 mg/kg was used as reference standard. It has been observed that the aqueous extract and ethanolic extract showed maximum percentage protection towards inflammation in comparison to other extracts. The plant Euphorbia hirta reduces inflammation and prevents the development of experimentally induced inflammation in rats. 


Key Words : Carragenan, Diclofenac Sodium, prostaglandin, edematogenic, inflammation.  

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