Formulation and in vitro-in vivo evaluation of Salbutamol Sulphate sustained release tablets

By Abhijit N. Merekar, Rahul K. Godge, Smita K. Parjane, Bhanudas S. Kuchekar, Prakash N. Kendre, Prasad P. Tagalpallewar and Nachiket S Dighe

Abstract

The objective of this study was to formulate and evaluate a matrix system for sustained and simultaneous delivery of anti-asthmatic drug Salbutamol sulphate .which is often indicated for the management of asthma, their frequent dosing may reduce compliance, thus making prolonged release formulation necessary. The matrix tablets were prepared by wet granulation method using Ion exchange resins. The granules showed satisfactory flow properties and compressibility. All the five tablet formulations showed acceptable pharmacotechnical properties and complied with the in-house specifications for tested parameters. They are evaluated for angle of repose, friability, hardness, disintegration and dissolution.

 

Key Words : Antiasthmatic, Ion exchange resin, Salbutamol sulphate, Sustained release Formulation.

 

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